The fall of Byzantine Constantinople culminated on May 29, 1453 as part of a 53-day Ottoman siege which had begun on April 6. The attacking Ottoman Army, which significantly outnumbered Constantinople's defenders, was commanded by the 21-year-old Sultan Mehmed II (later nicknamed "the Conqueror"), while the Byzantine army was led by Emperor Constantine XI Palaiologos.
The conquest of Constantinople and the fall of the Byzantine Empire was a watershed of the Late Middle Ages, marking the effective end of the last remains of the Roman Empire, a state which began in roughly 27 B.C. and had lasted nearly 1500 years. Among many modern historians, the fall of Constantinople is considered the end of the medieval period. The city's fall also stood as a turning point in military history. Since ancient times, cities and castles had depended upon ramparts and walls to repel invaders. The Walls of Constantinople, especially the Theodosian Walls, were some of the most advanced defensive systems in the world at the time. These fortifications were overcome with the use of gunpowder, specifically in the form of large cannons and bombards, heralding a change in siege warfare.
According to the Encyclopædia Britannica, Mehmed II "permitted an initial period of looting that saw the destruction of many Orthodox churches", but tried to prevent a complete sack of the city. On June 2, the Sultan found the city largely deserted and half in ruins; churches had been desecrated and stripped, houses were no longer habitable, and stores and shops were emptied. He is famously reported to have been moved to tears by this, saying, "What a city we have given over to plunder and destruction."
Looting was carried out on a massive scale by sailors and marines who entered the city via other walls before they had been suppressed by regular troops, who were beyond the main gate. According to David Nicolle, the ordinary people were treated better by their Ottoman conquerors than their ancestors had been by Crusaders back in 1204, stating that only about 4,000 Greeks died in the siege, while according to a Venetian Senate report, 50 Venetian noblemen and over 500 other Venetian civilians died during the siege. Many of the riches of the city were already looted in 1204, leaving only limited loot to the Ottomans.